Blar i forfatter "Wang, Jianhe"
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Nutrient Availability and Phage Exposure Alter the Quorum-Sensing and CRISPR-Cas-Controlled Population Dynamics of Pseudomonas aeruginosa
Ahator, Stephen Dela; Sagar, Sadhanna; Zhu, Minya; Wang, Jianhe; Zhang, Lian-Hui (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-14)Quorum sensing (QS) coordinates bacterial communication and cooperation essential for virulence and dominance in polymicrobial settings. QS also regulates the CRISPR-Cas system for targeted defense against parasitic genomes from phages and horizontal gene transfer. Although the QS and CRISPR-Cas systems are vital for bacterial survival, they undergo frequent selection in response to biotic and abiotic ... -
The virulence factor regulator and quorum sensing regulate the type I-F CRISPR-Cas mediated horizontal gene transfer in Pseudomonas aeruginosa
Ahator, Stephen Dela; Liu, Yang; Wang, Jianhe; Zhang, Lian-Hui (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-30)Pseudomonas aeruginosa is capable of thriving in diverse environments due to its network of regulatory components for effective response to stress factors. The survival of the bacteria is also dependent on the ability to discriminate between the acquisition of beneficial and non-beneficial genetic materials via horizontal gene transfer (HGT). Thus, bacteria have evolved the CRISPR-Cas adaptive immune ...